![]() ![]() ![]() The pangenome represents "a milestone in human genetics", but challenges remain, two US experts, Arya Massarat and Melissa Gymrek, warned in Nature.Īs well as including more samples from currently under-represented groups, adoption will take time as scientists need to be trained how to use the new reference, they said. ![]() "This paper heralds a new age of genetic diagnosis, that will benefit people from all ancestries, unlike our current reference genome that does not reflect all the diversity of humanity," he said. It could also help better match organ transplant donors with patients, he added in a statement.ĭavid Adelson, an expert in genetics at Australia's University of Adelaide who was not involved in the research, said that even in the draft phase, the pangenome had already increased the accuracy of detecting genetic changes by 34 per cent. "It was impossible to study MHC diversity" previously because it differs so much between every person, Jarvis said.īut the pangenome reference "will help us understand how immune responses against specific pathogens vary among people," he said. "This will ultimately help improve genetic testing and simultaneously give us a clearer understanding of the contribution of all types of genetic variation to health and disease," he told an online press conference.Īnother study co-author, Erich Jarvis of Rockefeller University, said just one example was gene clusters known as major histocompatibility complex (MHC), which are involved in the body's immune system. One of the study co-authors, Benedict Paten of the University of California, said it would make it easier to spot small differences in new genetic samples. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |